The ketogenic diet is usually initiated in combination with the patient's existing anticonvulsant regimen, though patients may be weaned off anticonvulsants if the diet is successful. Some evidence of synergistic benefits is seen when the diet is combined with the vagus nerve stimulator or with the drug zonisamide, and that the diet may be less successful in children receiving phenobarbital.[18]
It is important to find out from your doctor whether any medications that you take affect how your body uses what you eat. For instance, some medications cause a person to retain sodium, while others cause potassium loss. Methotrexate can lower folic acid levels, causing a variety of adverse symptoms that can be offset by taking additional supplements.
Of course, there are so many more reasons to exercise, and physical activity is amazing for your overall health and wellness. It’s just that if you want to lose weight, it may not be the best or only answer. “Honestly, I think people just don’t know where to start,” says Mangieri. “It’s easy to say you’re going to go to the gym for an hour. It’s much harder to think about what you’re eating all day, every day.” She recommends setting goals that are just as specific and achievable for healthy eating, which could be as simple as drinking a big glass of water right when you wake up, getting protein at breakfast, filling half of your plate with colorful vegetables, or going for a walk in the evening, instead of eating ice cream on the couch.
In its 2016 report “Healthy Eating Guidelines & Weight Loss Advice,” the Public Health Collaboration, a U.K. nonprofit, evaluated evidence on low-carbohydrate, high-fat diets. (The Keto diet falls under the LCHF umbrella.) Among 53 randomized clinical trials comparing LCHF diets to calorie-counting, low-fat diets, a majority of studies showed greater weight loss for the Keto-type diets, along with more beneficial health outcomes. The collaboration recommends weight-loss guidelines that include a low-carbohydrate, high-fat diet of real (rather than processed) foods as an acceptable, effective and safe approach.
If you’re like many resolution setters this time of year, you’ve already mapped out a route to your local gym. Maybe you’re planning to pound the treadmills or sweat it out in crowded studio classes. But if your ultimate goal is to drop extra pounds, you might want to ask how far all those miles and squats will really get you. According to a number of weight loss experts, focusing on your nutrition could give you a lot more bang for your buck. “By far, diet outweighs exercise if you want to lose weight,” says Heather Mangieri, RDN and spokesperson for the Academy of Nutrition and Dietetics. “You have to change your diet to change body composition. You can never out-exercise a bad diet.” So don’t sweat it—at least not quite so much. Here’s where to start with a weight loss resolution.
Because some cancer cells are inefficient in processing ketone bodies for energy, the ketogenic diet has also been suggested as a treatment for cancer.[59][60] A 2018 review looked at the evidence from preclinical and clinical studies of ketogenic diets in cancer therapy. The clinical studies in humans are typically very small, with some providing weak evidence for anti-tumour effect, particularly for glioblastoma, but in other cancers and studies, no anti-tumour effect was seen. Taken together, results from preclinical studies, albeit sometimes contradictory, tend to support an anti-tumor effect rather than a pro-tumor effect of the KD for most solid cancers.[61]
Having ready-to-eat snacks and meals-in-minutes on hand sets you up for success. You'll be less likely to hit the drive-through or order a pizza if you can throw together a healthy meal in five or 10 minutes. Here are some essentials to keep on hand: frozen vegetables, whole-grain pasta, reduced-fat cheese, canned tomatoes, canned beans, pre-cooked grilled chicken breast, whole grain tortillas or pitas, and bags of salad greens.
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